Pharm phun

Two drugs, almost identical molecular structure, very different actions.

Before there was viagra, there was alprostadil. This is a prostaglandin (PGE 1). It is given by penile injection to cause vasodilation and erection. Ouch...

Another drug, dinoprostone, another prostaglandin (PGE 2), is administered vaginally. Given in early pregnancy, it is abortifacient, meaning it causes an abortion. Given in late pregnancy, it causes uterine muscle contraction and induction of labor.

Two drugs, almost identical chemical structure, very different results. Interesting.

Long awaited return

I must apologize to those who have been checking this blog daily only to find that they will not get their random medical fact fix. But alas, i return, only to issue a grave warning.

Haemophilus influenza - this small gram negative coccobacilli has all but been eliminated from the united states. But, like so many other diseases, this one to tends to prey on those other countries unalbe to afford vaccinations. The full name, Haemophilus influenzae biogroup aegyptius, is alive and well in South America. It causes Brazilian purpuric fever. Symptoms begin with conjunctivitis that develops into a fever, petechiae (small pinpoint bleeds), then purpura (larger hemorrhages) and eventually septic shock. This has a high mortality rate.

So, if you happen to know three lost travelers making their way through South America, do tell them to stay clear of the dreaded Hemophilus influenza biogroup aegyptius!!!