alcohol poll and dysdiadochokinesis

i'm a little surprised at the poll results. some have quite a bit of alcohol experience(zero order kinetics), some have none (i have no idea or first order kinetics), and others are just plain alcoholics (mmm... alcohol). it turns out, as emily so expertly pointed out that alcohol is a mixed order or dose dependent. when a drugs elimiation is mediated predominantly by metabolism, its elimination will tend to follow first order kinetics when concentrations are well below the Km of the metabolic enzymes, but will follow zero order kinetics at high doses that greatly exceed the Km of the metabolic enzymes due to saturation of the metabolic pathways. alcohol is one such drug.

so congrats to those of you who voted, you're all a little wrong, and all sort of correct. just remember... "you don't booze, you don't win. you booze you win. you don't booze you don't race you don't win, you booze you race you win."

dysdiadochokinesis: the ability to preform rapidly alternating movements. this is impared in cerebellar damage. so whatever you do this fine weekend, don't damage your cerebellum!